Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain
نویسندگان
چکیده
منابع مشابه
Analytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
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The chemical exchange saturation transfer (CEST) effect on an egg white (EW) suspension was investigated for optimization of magnetization transfer (MT) power (B1,rms) and pH dependency with the addition of lactic acid. Applying a higher MT pulse, B1,rms, Z-spectrum shows higher asymmetry and the magnetisation transfer ratio (MTR)asym signal increases to around 1-3.5 ppm, indicating a higher CE...
متن کاملImaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT).
PURPOSE This study investigates amide proton transfer (APT) and nuclear overhauser enhancement (NOE) in phantoms and 9L tumors in rat brains at 9.4 Tesla, using a recently developed method that can isolate different contributions to exchange. METHODS Chemical exchange rotation transfer (CERT) was used to quantify APT and NOEs through subtraction of signals acquired at two irradiation flip ang...
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Nearest-neighbor inductive effects are known to influence amide proton exchange. Here we show that longrange electrostatic interactions also have a significant effect on the rate of amide proton exchange. We have measured the effects of salt (NaC1) on the exchange rates of the neutral polypeptide poly(DL-alanine) (PDLA) and of the positively charged polymer poly(DL-lysine) (PDLL). Our results s...
متن کاملProton Exchange in a Paramagnetic Chemical Exchange Saturation Transfer Agent from Experimental Studies and ab Initio Metadynamics Simulation.
The proton-exchange process between water and a carbamate has been studied experimentally and theoretically in a lanthanide-based paramagnetic chemical exchange saturation transfer agent endowed with potential multimodality detection capabilities (optical imaging, or T1 MRI for the Gd(III) analogue). In addition to an in-depth structural analysis by a combined approach (using X-ray crystallogra...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2019
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2019.01.034